PT-141

Base Peptides are intended for licensed medical professionals and experienced researchers. Reconstitution required. Dosing and use instructions are not provided.

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PT-141 (Bremelanotide) — Cyclic Heptapeptide Melanocortin Agonist

PT-141 (Bremelanotide) is a cyclic heptapeptide derived from the melanocortin family and studied for central melanocortin (MC) pathway activation, especially MC3R/MC4R in the brain. Research focuses include sexual behavior neurobiology, energy-balance signaling, and melanocortin receptor pharmacology. [oai_citation:0‡PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC8788464/?utm_source=chatgpt.com)

Identifiers

CAS: 189691-06-3 [oai_citation:1‡Wikipedia](https://en.wikipedia.org/wiki/Bremelanotide?utm_source=chatgpt.com)
PubChem CID: 9941379 [oai_citation:2‡PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Bremelanotide?utm_source=chatgpt.com)
Formula / MW: C₅₀H₆₈N₁₄O₁₀ · ~1025 g·mol⁻¹ (free base) [oai_citation:3‡PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/Bremelanotide?utm_source=chatgpt.com)
Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (α-MSH analogue) [oai_citation:4‡FDA Access Data](https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/210557Orig1s000OtherR.pdf?utm_source=chatgpt.com)
Common names: PT-141; Bremelanotide (USAN); tradename “Vyleesi” (device/finished drug). [oai_citation:5‡Wikipedia](https://en.wikipedia.org/wiki/Bremelanotide?utm_source=chatgpt.com)

How It Works (Plain English)

Acts as a melanocortin receptor agonist, with predominant activity at MC3R/MC4R, pathways tied to sexual behavior circuits and energy homeostasis. [oai_citation:6‡PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC8788464/?utm_source=chatgpt.com)
Unlike peripherally focused agents, PT-141’s effects are studied mainly via central receptor signaling (hypothalamic networks). [oai_citation:7‡PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC2694735/?utm_source=chatgpt.com)
As an α-MSH-family analogue, it lacks vasodilator/NO dependence—useful for dissecting non-NO sexual arousal mechanisms in models. [oai_citation:8‡PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC2694735/?utm_source=chatgpt.com)

Why Researchers Use It

To probe MC3R/MC4R pharmacology and neural circuits regulating arousal, appetite, and stress response. [oai_citation:9‡PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC8788464/?utm_source=chatgpt.com)
To build translational bridges from receptor activation → behavioral endpoints (questionnaires, neuroendocrine measures). [oai_citation:10‡PubMed](https://pubmed.ncbi.nlm.nih.gov/31599840/?utm_source=chatgpt.com)
To compare melanocortin agonists (e.g., setmelanotide for MC4R) across energy-balance pathways. [oai_citation:11‡ScienceDirect](https://www.sciencedirect.com/science/article/pii/S2212877821000466?utm_source=chatgpt.com)

Key Studies — What Was Tested, What Changed, Why It Matters

Phase 3 HSDD trials (human) — central MC pathway engagement

What was tested: Two randomized, double-blind, placebo-controlled Phase 3 trials in premenopausal women with HSDD. [oai_citation:12‡PubMed](https://pubmed.ncbi.nlm.nih.gov/31599840/?utm_source=chatgpt.com)
What changed: Significant improvements on sexual-desire and distress scales vs placebo; most AEs were mild–moderate (nausea, flushing, headache). [oai_citation:13‡PubMed](https://pubmed.ncbi.nlm.nih.gov/31599840/?utm_source=chatgpt.com)
Why it matters: Confirms that **melanocortin signaling** can modulate human arousal endpoints—useful for mechanistic and translational research frameworks.

Mechanism & safety context from FDA dossiers

What was reviewed: FDA label/NDAs summarizing PK/PD and safety signals in clinical use. [oai_citation:14‡FDA Access Data](https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf?utm_source=chatgpt.com)
What changed: Repeated finding of transient BP increases and HR reduction post-dose; labeling warns against use in uncontrolled hypertension. [oai_citation:15‡FDA Access Data](https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf?utm_source=chatgpt.com)
Why it matters: For lab work, plan cardiovascular monitoring endpoints if your model requires systemic exposure.

Potential Research Applications

Neurobehavioral Models

Central MC3R/MC4R pathway studies
Behavioral assays + endocrine readouts

Energy-Balance & Stress

MC4R-linked feeding/energy studies (comparators like setmelanotide)
HPA-axis and autonomic endpoints

Receptor Pharmacology

Agonist selectivity (MC1R–MC5R) & biased signaling
Off-target pigmentation pathways (context-dependent)

Synergistic Peptides (for Study Design)

Oxytocin

Why pair: Complementary neuropeptide for social/affiliative circuits alongside melanocortin pathways.
Angle: Cross-over designs to parse amygdala–hypothalamus networks.

Selank / Semax

Why pair: Neuroimmune/neurotrophic modulators to profile mood-stress context alongside arousal endpoints.
Angle: Cytokine/BDNF arrays + behavioral tasks.

Setmelanotide

Why pair: MC4R-selective comparator to contrast **selectivity vs breadth** within the melanocortin family. [oai_citation:16‡ScienceDirect](https://www.sciencedirect.com/science/article/pii/S2212877821000466?utm_source=chatgpt.com)
Angle: Side-by-side receptor occupancy and downstream signaling.

Design Notes

Declare salt/form (e.g., acetate) and vehicle; peptide adsorption and pH matter.
For systemic models, predefine cardiovascular endpoints (BP/HR) given label findings. [oai_citation:17‡FDA Access Data](https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf?utm_source=chatgpt.com)
Use appropriate controls (vehicle, single-agent comparators) for mechanism clarity.

Known Concerns (Context)

Transient cardiovascular effects: Short-lived increases in blood pressure and reductions in heart rate reported post-dose. [oai_citation:18‡FDA Access Data](https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210557s000lbl.pdf?utm_source=chatgpt.com)
Nausea/headache & hyperpigmentation: Common tolerability signals; pigmentation is mechanism-linked in some models. [oai_citation:19‡PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC8788464/?utm_source=chatgpt.com)
General: Research use only; not for human consumption or therapeutic use.

Specifications & Handling

Form: Lyophilized powder (lot-coded)
Purity: ≥ 99% (HPLC/MS verified)
Storage: ≤ −20 °C; protect from light/moisture

In solution: Prepare fresh aliquots; avoid repeat freeze–thaw
Packaging: Tamper-evident; research-only labeling

Regulatory & Use Notice

Sold for laboratory research use only. Not for human consumption, medical, or veterinary use. No human-use instructions are provided. Buyer is responsible for safe handling and regulatory compliance.

PT-141 (Bremelanotide) Peptide Research | Melanocortin (MC3R/MC4R) Agonist | Neurobehavior & Energy-Balance Studies

Keywords: PT-141, Bremelanotide, melanocortin agonist, MC4R, MC3R, α-MSH analogue, sexual behavior research, energy balance, Base Peptides.

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Instructions are NOT provided before or after purchase.

Peptide molecules are unfinished and require reconstitution from a skilled and licensed professional to activate the compound into liquid form. Instructions are not provided for reconstitution, dosing, or adminstration. All products are strictly intended for research purposes and laboratory experimentation. Handling should be by skilled licensed and credentialed professionals only. Non experimental use is strictly prohibited.

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